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滋養細胞腫瘤之子宮切除

The Role of Hysterectomy for Gestational Trophoblastic Disease

摘要


對高危險之妊娠滋養細胞腫瘤,化學治療爲標準的治療方法,大多效果很好,可減少使用手術治療的機會。但在特殊狀況,如有嚴重陰道出血、腹腔內大出血、胎盤位滋養細胞腫瘤、和類上皮滋養細胞腫瘤等時,可能要考慮切除子宮。特別當滋養細胞瘤之病灶侷限在子宮,患者又不再生育時,應告知患者子宮切除爲輔助之治療方法。有些作者仍認爲早期手術加上化學治療,可以減少全部化學治療的療程,及減少化學治療引起的副作用。

並列摘要


The combination chemotherapy is recommended as the cornerstone for treatment of the women with high-risk gestational trophoblastic disease. The excellent results of chemotherapy have diminished the role of operative interventions. However, elective hysterectomy aiming at curing the patients plays a minor but definitive role in elected patients, with massive vaginal hemorrhage intrauterine bleeding, placental site trophoblastic tumor and epitheloid trophoblastic tumor as and indication surgery. If the lesions of gestational trophoblastic disease are confined to the uterus and the woman has no desire to preserve infertility, she should be informed of adjuvant hysterectomy as a treatment option. With the increasing use of early surgical intervention with chemotherapy, some authors thought that it might decrease the number of chemotherapeutic cycles necessary to achieve remission and in effect decreasing the exposure of the patients to toxicity from the chemotherapy.

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