The combination chemotherapy is recommended as the cornerstone for treatment of the women with high-risk gestational trophoblastic disease. The excellent results of chemotherapy have diminished the role of operative interventions. However, elective hysterectomy aiming at curing the patients plays a minor but definitive role in elected patients, with massive vaginal hemorrhage intrauterine bleeding, placental site trophoblastic tumor and epitheloid trophoblastic tumor as and indication surgery. If the lesions of gestational trophoblastic disease are confined to the uterus and the woman has no desire to preserve infertility, she should be informed of adjuvant hysterectomy as a treatment option. With the increasing use of early surgical intervention with chemotherapy, some authors thought that it might decrease the number of chemotherapeutic cycles necessary to achieve remission and in effect decreasing the exposure of the patients to toxicity from the chemotherapy.