並列摘要
Cyclooxygenase (COX), the key enzyme in the conversion of arachidonic acid to prostaglandins, exists in two isoforms: COX-1 and COX-2. COX-2 expression appears to be related to cancer proliferation, mitosis, immunoreaction, angiogenesis, and a suppression of apoptosis. The development of specific COX-2 inhibitors has led to new concepts of chemoprevention and treatment of cancer. In recent studies, celecoxib (COX-2 inhibitor) has shown potential as an adjuvant medical treatment for cervical cancer. Further trials with larger numbers are needed to confirm these results.
延伸閱讀
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