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摘要


針對早期子宮內膜癌病人,賀爾蒙治療用於保留生育能力雖不是標準作法,但此處理方式可能可以接受。但是其前提必須,病人和醫療團隊在治療前需達成共識,進行部分或完全保留生育能力的處置。其他如腫瘤相關風險,病人對於疾病復發或轉移的疑慮,醫療團隊的建議和經濟負擔都是必須考慮的因素。至於晚期,復發或轉移性子宮內膜癌,賀爾蒙治療的成果似乎不太理想,但單獨使用黃體素或和泰莫希芬合併使用對一些附合條件的病人,或許是另外一項治療的選擇。雖然按照目前的數據結果,使用賀爾蒙療法治癒的可能性很低,但低毒性可以減輕病人身體上的負擔。隨著分子學發展的進步,或許能提高賀爾蒙對子宮內膜癌的治療效果。

並列摘要


The use of hormone, especially progestin, in the management of an early-stage endometrial cancer is acceptable in the young women, although it is not a standard therapy. Before the use of conservative therapy in these patients, many criteria should be fulfilled, including a well-trained team, the oncologic risk, appropriate candidates, type of hormone use, response rate of hormonal therapy, appropriate surveillance, additional counseling for anxiety about relapse and metastasis, distress about side-effects, advice of the family, advice of the medical staff, and economic burden. For those patients with advanced or recurrent endometrial cancers, therapeutic effectiveness is not satisfactory, but the use of progestin with/without tamoxifen could be considered, based on the minimal side effects of these treatments. A further better understanding of mechanism of hormones on endometrial cancers might increase the effects of hormones on endometrial cancers.

並列關鍵字

endometrial cancer hormone therapy

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