使用Ocusert-pilocarpine對治療青光眼的經驗

Experience on the Treatment of Glaucoma with Ocusert-Pilocarpine

侯平康(Ping-Kang Hou)

《中華民國眼科醫學會會刊》 16卷 (1977/05) Pp. 42-45

https://doi.org/10.30048/ACTASOS.197705.0008

摘要

Ocusert-pilocarpine為新開發之持續型薄膜控制pilocarpine釋放系統，本試驗使用此系統於29例對傳統性pilocarpine點眼反應良好之隅角開放性青光眼症例，顯示病人不耐受性佔約10%，眼壓控制滿意者約80%。pilo-20適用於原來使用1% pilocarpine點眼液者，pilo-40適用於原來使用2~4 % pilocarpine點眼液者，而有效持續時間至少一星期。無明顯的副作用，亦無對眼的傷害或感染事情發生。對於傳統pilocarpine點眼易引起的縮憧或屈光變動等副作用較不明顯，為其優點。似可推廣使用於pilocarpine反應良好之青光眼病人的治療。

並列摘要

Twenty-nine patients with open-angle glaucoma who were responsive to pilocarpine have been studied from 4 weeks to 3 months regarding their response to the use of Ocusert-pilocarpine. Patients placed the system in the cul-de-sac once a week. They retained it well and tolerated its continuing use without appreciable difficulty except 2 cases. Magnitude of pressure reduction with release rates of 20 mcg and 40 mcg of pilocarpine per hour were as effective in the treatment of glaucoma as 1 percent and 2 to 4 percent pilocarpine eye drops respectively, except 3 cases. The duration of effect is at least 7 days. Side effects from the Ocusert were mininal or absent. The advantages of Ocusert-pilocarpine over eyedrops are better patient compliance and convenience, around-the-clock protection, reduced untoward side effects associated with transient overdose of pilocarpine such as sustained miosis and change of refractory state.

並列關鍵字

pilocarpine ； membrane-controlled pilocarpine delivery system ； Ocusert pilo-20 ； Ocusert pilo-40