氬氣雷射虹膜穿孔術後眼壓升高之預防

Prevention of Intraocular Pressure Elevation after Argon Laser Iridotomy

鄧美琴(Mei-Ching Teng) ； 賴盈州(Ing-Chou Lai) ； 李瑞鋒(Zwei-Fung Lee)

《中華民國眼科醫學會會刊》 26卷1期 (1987/05) Pp. 46-51

https://doi.org/10.30048/ACTASOS.198705.0009

摘要

對100隻眼施行氬氣雷射虹膜穿孔術，其中20隻眼當作對照組，28眼於雷射前1小時點0.25% Timo101, 52例於雷射前1小時服用250mg Acetazolamide，結果術前給藥的兩組眼睛發生術後眼壓升高的比率及幅度均比對照組減少許多。術後眼壓上升的平均值，對照組為3.10±4.80mmHg，Timolol使用組為0.64±2.56mmHg, Acetazolamide使用組為-0.31±2.15mmHg。術後眼壓上升大於5mmHg以上的，對照組有30%，Timolol使用組14.3%，Acetazolamide使用組只有7.7%。術後眼壓上升大於10mmHg以上的，對照組有10%，Timolol和Acetazolamide使用組為0%。

並列摘要

Transient intraocular pressure elevation after argon laser iridotomy is common & potentially, can be of much greater risk to an eye with advanced chronic angle closure glaucoma. Our study was designed to determine if pretreated with 0.25% timolol or 250mg acetazolamide 1 hour before argon laser iridotomy would prevent these transient pressure rises. Our results showed that 30% (6/20) of control eyes had an elevation of intraocular pressure ＞5mmHg. Only 14.3% (4/28) of the timolol-pretreated eyes and 7.7% (4/52) of the acetazolamide-pretreated eyes had an elevation of intraocular pressure ＞5mmHg. 10% (2/20) of control eyes had a past-laser intraocular pressure＞10mmHg. While none of the pretreated eyes had a rise that magnitude. The mean maximum intraocular pressure elevation was 3.10±4.80 mmHg in the control eyes, 0.64±2.56 mmHg in the timolol-pretreated eyes, -0.31±2.15 mmHg in the acetazolamide-pretreated eyes. Our results suggest that pretreatment with 0.25% timolol or 250 mg acetazolamide before argon laser iridotomy provide partial protection from intraocular pressure elevation. This partial protection may be used to prophylactically treat those patients who are particularly susceptible to elevated intraocular pressure or whose baseline pressure is higher, or who has required more than the usual amount of laser treatment.

並列關鍵字

timolol ； acetazolamide