0.1% Indomethacin眼藥水用於白內障手術之效應

本文在研究0.1% Indomethacin眼藥水對於白內障手術的效應。本研究共收集三十例白內障病患，其中二十雙患眼在術前及術後投予0.1% Indomethacin眼藥水，另外十雙患眼僅接受一般白內障術前術後藥物。我們在術中量取各個步驟瞳孔大小變化；術前術後中心角膜厚度；眼壓以及前房發炎反應。結果顯示0.1% Indomethacin眼藥水可以防止白內障之術中縮瞳，並可降低術後前房發炎反應，及促進術後角膜水腫期恢復；但是對眼壓的影響則不具統計學上的意義。本文並將探討Indomethacin眼藥水對於防止術中縮瞳及抗炎性反應的藥理學機轉。

關鍵字

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並列摘要

Indomethacin is a non-steroid anti-inflammatory agent, it has both anti-inflammatory and antiprostaglandin effect. It was suggested before that topical use of Indomethacin might prevent intraoperative miosis and transient postopreative ocular hypertenstion. It may reduce postoperative inflammation and corneal edema, too. So we designed the following study to evaluate the topical use of 0.1% Indomethacin eyedrops on cataract surgery. We collected 30 cataract eyes, 20 eyes belong to the study group and 10 eyes in the control group. In addition to the routine preoperative and postoperative medications, the eyes in the study group received 0.1% Indomethacin eyedrops from one day before surgery until two weeks after surgery. The eyes in the control group received routine preoperative and postoperative medications only. The results reveal that topical use of 0.1% Indomethacin eyedrops prevented intraoperative miosis, reduced postoperative anterior chamber reaction and promoted early recovery of postoperative corneal edema. But the intraocular pressure of the two groups showed no statistical significant difference.

並列關鍵字

Indomethacin ； non-steroid anti-inflammatory agents ； ECCE ； Anti-prostaglandin

國際替代計量

0.1% Indomethacin眼藥水用於白內障手術之效應

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