IOPIDINE對青光眼雷射術後眼壓變化之影響

Effect of Iopidine (Apraclonidine) on Intraocular Pressure Change after Laser Treatment of Glaucoma Eyes

周清光(Joe C. K. Chou) ； 王安國(An-Kao Wang) ； 許淑娟(Su-Juen Hsu) ； 陳瑛瑛(Ing-Ing Chen)

《中華民國眼科醫學會會刊》 29卷1期 (1990/05) Pp. 258-262

https://doi.org/10.30048/ACTASOS.199005.0046

摘要

本實驗研究Iopidine對於氬氣雷射隅角成形術(argon laser gonioplasty，ALG)及釹雅克雷射虹膜穿孔術(Nd: YAG laser iridectomy，YPI)術後眼壓變化之影響，在我們的雙盲追踪研究中，33隻病眼在雷射治療前後各點一滴Iopidine或Timolol作為實驗組，22隻病眼雷射前後均不點藥作為對照組，在ALG治療中，無論實驗組與對照組平均眼壓變化均無統計意義，且沒有任何一隻病眼眼壓上昇超過10mmHg，在YPI治療中，Iopidine組與Timolol組有意義地降低雷射後平均眼壓，同時，Iopidine組與Timolol組沒有病眼的眼壓上昇超過10mmHg，而對照組中有3隻病眼眼壓上昇超過10mmHg，Iopidine對於YPI治療後的眼壓控制具有相當的效果。

並列摘要

55 glaucoma eyes received argon laser gonioplasty (ALG) or Nd: YAG laser iridectomy (YPI) were included in this study. 1% iopidine, or 0.5% timolol was dropped into the right eye 30 minutes before and immediately after laser treatment. Placebo was dropped into the left eye as control.
In YPI group, 3 eyes with placebo showed marked elevation of intraocular pressure (IOP) over 10 mmHg. Eyes with iopidine or timolol showed only mild elevation of IOP (less than 5 mmHg). There were no differences between iopidine and timolol group.
In ALG group, none of them showed marked elevation of IOP, even in eyes with placebo. In this group they has used timolol as regular treatment. Maybe it would interfere and mask the effect of added pre- and post-laser medications.
Iopidine (aproaclonid me) pretretament and immediate post laser management really can eliminate the abrupt elevation of intraocular pressure.

並列關鍵字

Iopidine ； Timolol ； Laser iridectomy ； Laser gonioplasty ； Intraocular Pressure