- 期刊
- OpenAccess
臘腸桿茵毒素治療良性眼瞼痙攣之臨床試驗
Treatment of Essential Blepharospasm with Botulinum Toxin-A Preliminary Report
摘要
28位眼瞼痙攣患者；其中20位為良性眼瞼痙攣，8位為Meige症狀群；接受臘腸桿菌毒素皮下注射於眼瞼及眉毛部位。所有患者都接受相同劑量與相同部位之臘腸桿菌毒素治療，每側接受12.5單位，兩側共25單位臘腸桿菌毒素注射。研究顯示臘腸桿菌毒素對良性眼瞼痙攣是非常安全有效的治療方法，雖然治療的效果是暫時性的，但大部份的病人在接受第一次注射，平均可達到11.7週的症狀紓解期，痙攣程度自注射前之3.5，降為0.8。副作用包括有眼瞼下垂、淚溢、乾眼症等，但症狀都輕微、短暫。沒有任何全身性的副作用發生。臘腸桿菌毒素目前成為治療良性眼瞼痙攣的第一優先選擇的趨勢，從本臨床試驗得到肯定。
關鍵字
無資料並列摘要
Twenty-eight patients, 20 with essential blepharospasm and 8 with Meige syndrome, received botulinum toxin by subcutaneous injections in the eyelids and eyebrows. Three had residual spasm following previous myectomy procedure. All received a standard treatment of 12.5 units of botulinum toxin in each side. The treatment was effective in most patients (93%), althrough transient, the mean duration of relief of spasm after the first injections being 11.7 weeks. The spasm intensity decreased from 3.5 to 0.8. Side effects including ptosis, epiphora, dry eye and photophobia were mild, transient and well-tolerated. Botulinum toxin as an initial treatment or as an adjavunt in postsurgical residual blepharospasm shows promise in this study.
延伸閱讀
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