實驗性近視之研究Ⅱ Atropine和Homatropine對雞近視的作用

Study on Experimental Myopia Ⅱ Atropine and Homatropine Effects on Chick Myopia

施永豐(Yung-Feng Shih) ； 林隆光(Luke L.K. Lin) ； 王勢爵(Shih-Chueh Wang) ； 柯良時(Liang-Shi Ko)

《中華民國眼科醫學會雜誌》 32卷1期 (1993/03) Pp. 29-35

https://doi.org/10.30048/ACTASOS.199303.0005

摘要

近距離作業所引起的過度調視被認為是近視產生的最重要機轉。所以，減少過度調視或放鬆因調視過度所產生的睫狀肌痙孿可能是預防近視的方法。本篇利用1% Atropine和Homatropine來點於眼瞼縫合以引發近視的雞眼睛，每日一次。八週後，Atropine和Homatropine在前兩三週可以使赤道徑大小減少，但十週後則和對照組類似無作用。然而，眼軸長均比對照組為長，以上統計上雖無有意義差別。但由以上結果，可以知道在雞的眼瞼縫合引發的近視，停止調視機能並不能預防近視產生，所以調視作用可能不是近視產生的唯一機轉。

並列摘要

Accommodation have been suggested to play a role in the experimental eye growth and the development of myopia. Therefore, blockade of accommodation by instillation of atropine sulfate and homatropine had been suggested to prevent the myopia. In this paper, we sought to investigate directly that myopia develops as a consequence of an accommodation change by pharmacologically cancelling accommodation during postnatal development. Either 1% atropine or homatropine or normal saline was applied to the eyes of chicks which will become myopia due to lid suture during postnatal development. After 8 weeks, all the equatorial size, axial length and corneal diameter were measured. Both of the atropine and homatropine groups, the equatorial size was slightly decrease during first 2 to 3 weeks, but become similar to the control saline group after tenth week. Surprisingly, axial length was slightly increased than that of the control group. These results suggested that blockade of accommodation can not prevent lid-suture induced myopia in chicks. Thus, accommodation may not play an important factor in chick myopia.

並列關鍵字

Accommodation ； Myopia ； Atropine ； Homatropine ； Chick