手術中使用Mitomycin C局部浸漬法治療翼狀贅片之結果

Intraoperative Application of Mitomycin C in the Treatment of Pterygium

游琇瑾(Shew-Gin Yow) ； 郭錫恭(His-Kung Kou)

《中華民國眼科醫學會雜誌》 32卷1期 (1993/03) Pp. 55-59

https://doi.org/10.30048/ACTASOS.199303.0009

摘要

翼狀贅片之術後再發為其最常見之合併症。為防止再發，已有多種輔助療法，但均各有優缺點。本文提出一新的方法，使用Mitomycin C (0.25mg/ml)於手術中浸漬暴露之鞏膜床及鄰近之結膜下組織三分鐘，術後不再使用任何輔助療法，便能有效控制翼狀贅片之再發。本文收集高雄長庚醫院自民國79年3月至81年1月所作之病例共303例，350眼，回溯追蹤其再發率及合併症。結果追蹤期間從4個月到22個月，平約9.4個月，再發率為原發組23/335眼(6.9%)復發組1/15眼(6.7%)，合計24/350眼(6.9%)。合併症包括輕度角膜表皮點狀病變11眼(3.1%)，結膜延遲癒合5例(1.4%)及肉芽腫4例(1.1%)。向此結果推論，此種方法簡易有效，短期之副作用少，值得推廣與進一步探究其長期之效果。

並列摘要

Pterygium recurrence is a common complication after its excision. To prevent its recurrence after surgery, we developed a new method. Mitomycin C (0.25mg/ml) was applied to the bare sclera and adjascent subconjunctival tissue for 3 minutes during operation in 303 patients, 350 eyes. After 4-22 months of follow-up (mean 9.4 months), the recurrent rate was 24/350 (6.9%) totally, with 23/333 (6.95) in primary group and 1/15 (6.7%) in recurrent group. Complications are mild, including superficial punctate keratitis in 11 eyes (3.1%), conjunctival wound delayed healing in 5 eyes (1.4%) and granuloma formation in 4 eye (1.1%). This method was found to be simple, effective and safe, yet its long-term results are to be determined.

並列關鍵字

pterygium ； recurrence ； intraoperative mitomycin C