Effect of Indomethacin on Survival of Aeromonas Hydrophila Infected Tilapia, Oreochromis Mossambicus

Indomethacin對受Aeromonas hydrophila感染吳郭魚存活率之影響

蔡錦玲(Ching-Lin Tsai) ； 侯坤鋐(Kuan-Hong Hoh)

《Zoological Studies》 34卷1期 (1995/01) Pp. 59-61

摘要

魚體受病菌感染時會產生行為性發燒。行為性發燒是因為腦內體溫調節中樞的設定值（set point）提高，造成魚體嗜溫提高並游向高水溫區以增加體溫的現象。本研究以indomethacin（前列腺素合成抑制劑）投予受Aeromonas hydrophila感染的吳郭魚，比較其在近常溫25℃及高溫35℃下之死亡率。結果顯示indomethacin減少受A. hydrophila感染的吳郭魚在高溫35℃下的存活率。且，受A. hydrophila感染並投予indomethacin的吳郭魚在近常溫25℃下比在高溫35℃下有更高的存活率。此結果說明受A. hydrophila感染的吳郭魚嗜溫會增加，主要是經由前列腺素的作用。

關鍵字

前列腺素 ； 行為性發燒 ； 魚

並列摘要

Fish perform behavioral fever when infected by pathogenic bacteria. Behavioral fever is a phenomenon in which body temperature is regulated by an elevated brain set-point, thus raising the preferred temperature of the animal. The mechanisms of how the set-point is regulated in fish has been little studied. In this study, tilapia Oreochromis mossambicus were treated, under differing experimental conditions, with Aeromonas hydrophila, bacteria pathogenic to bony fish, and with indomethacin, a highly potent inhibitor of prostaglandin synthesis. Results show that indomethacin decreased the survival of A. hydrophila-treated O. mossambicus, under febrile temperatures (35°C). Indomethacin- and A. hydrophila-treated O. mossambicus had higher survival rates at normal temperatures than at febrile temperature conditions. These results demonstrate that infection by A. hydrophila can elevate the behaviorally preferred temperature of O. mossambicus. This process is mediated by prostaglandin.

並列關鍵字

Prostaglandin ； Behavioral fever ； Fish