A Simple Methodology for Preparing Synthetic Multiple-Interaction Chiral Stationary Phase Column for Chiral Drug Analysis

以光學活性靜相管柱分析光學活性藥物

蕭參(Gerald K. Shiu)

《藥物食品分析》 1卷4期 (1993/12) Pp. 335-339

摘要

本報告係描述一種簡單且容易製備的合成多重交互作用光學活性管柱，管柱固定相以衍生步驟合成，且易裝置於一般標準型的分析用高效液相層析儀。此管柱是一簡單，價低廉，各種大小的填充粒子與管柱長度皆適合，管柱的效率高，每10公分多於5000板，本文並以實例說明此管柱於分析生物體液及藥劑中消旋性藥物之應用。

並列摘要

A simple methodology for preparing synthetic multiple-interaction (SMI) chiral stationary phase (CSP) column is described in this report. The column was synthesized by an in situ derivatizing procedure and can be easily prepared with a standard analytical HPLC set-up. The column is a no frills, low cost one, and can be tailored to various packing particle sizes and column lengths. The efficiency of the column is high; over 5,000 plates per 10 cm. Applications on resolving some racemic drugs in plasma and formulation are illustrated.

並列關鍵字

Chiral stationary phase ； Enantiomers resolution ； Column preparation