Effect of Different Organized Media on Ion-Selective Electrode (ISE) Determination of Propranolol in Pharmaceutical Dosage Forms

以離子選擇電極檢測普潘奈藥物劑型中不同有序介質之影響

Dina El-Sherbiny ； Ghada Yehia Elewady ； Kamal Shalabi ； Abdelmonem El-Askalany

《藥物食品分析》 17卷2期 (2009/04) Pp. 85-92

並列摘要

This study examined the effect of different organized media such as β-cyclodextrin and micelle surfactants, either anionic (sodium dodecyl sulphate), cationic (cetrimide) or non-ionic (tween-20 and tween-80), on the potentiometric properties of propranolol polyvinyl chloride selective electrode based on tetraphenyl borate (PRO-TPB) ion-exchanger as an electroactive material. It was found that the Nernstian slope for propranolol over the concentration range of 1×10^(-5) to 10^(-2) M was unaffected by non ionic surfactant, whereas cationic surfactant significantly decreased the Nernstian slope. However, anionic surfactant significantly increased the Nernstian slope. The electrode basic analytical parameters such as measurement range, slope characteristics, detection limit, response time, and selectivity coefficients in relation to some inorganic cations, sugars, amino acids and some β-blockers were investigated in presence or absence of organized media. Electrode was used for the potentiometric determination of propranolol in pharmaceutical preparations with and without organized compounds. The results were consistent with those obtained using a reference method.

並列關鍵字

propranolol ； organized media ； ion selective electrode ； polyvinyl chloride ； selectivity coefficient ； dosage forms