摘要
背景：放射性碘-131應用於診斷與治療甲狀腺功能亢進症及甲狀腺癌，目前是首選方法。正確甲狀腺放射性碘攝取率測定對於放射性診斷或治療相當重要。臨床常用的甲狀腺放射性碘攝取率為服用放射性碘後24小時的測定值。本實驗旨在評估1小時量測值是否可用以預測24小時攝取率。方法：20隻Sprague-Dawley（SD）鼠用以檢視放射性部-131甲狀腺動態生物攝取率，確認最佳甲狀腺攝取率時間。另由20位疑似甲狀腺疾病患者測得1小時及24小時放射性碘-131甲狀腺攝取率。以線性迴歸法分析1小時與24小時甲狀腺放射性碘攝取率的關係。結果：由SD鼠實驗顯示在6小時頸部放射性碘攝取率為16.6%，而實際甲狀腺放射性碘攝取於為8.1%，所以6小時所測到頸部攝取是甲狀腺加上周邊背景組織放射活性，而在12、24及48小時測得頸部攝取率/實際甲狀腺攝取率分別為13.4%/12.5%、10.1%/10.5%及8.8%/9.9%，所以24小時所測到頸部攝取可視為實際甲狀腺攝取。線性迴歸分析病患1小時與24小時甲狀腺放射性碘攝取率關係式為y=50.0+0.518x，Pearson's相關係數r=0.347，其線性無法為統計學接受。結論：1小時甲狀腺放射性碘攝取率測值不適用於預測24小時攝取率。
並列摘要
Objective: Radioactive sodium iodide has long been the drug of choice for therapy and important to aid in diagnosis in patients with thyroid cancer and hyperthyroidism. The radioiodine uptake study is a useful diagnostic test for determination of the disease of the thyroid gland. Although the 24-h radioiodine uptake is used commonly, we evaluated the feasibility to predict 24-h thyroid uptake with 1-h uptake data.Methods: The radioiodide uptake and retention kinetics were studied in 20 SD rats to determine the optimum measurement time. Thyroid uptakes of twenty patients with suspected thyroid disorders were determined at 1 h and 24 h, respectively, after administration of radioiodide capsules. The data between 1-h and 24-h uptakes were analyzed by linear regression method.Results: In the SD rats, the neck uptake was 16.6% at 6 h after iodine-131 administration. However, the real thyroid uptake was only 8.1% at the same time. By 12, 24 and 48 h, the neck uptake/ real thyroid uptake was 13.4/12.5, 10.1/10.5 and 8.8/9.9, respectively. The 24-h neck uptake could be treated as the real thyroid uptake. The linear regression formula between 1-h and 24-h thyroid radioiodine uptakes of 20 patients was y = 50.0 + 0.158x with a Pearson's coefficient (r) of 0.347, which indicates a statistically unacceptable linearity of regression.Conclusion: The thyroid uptake determined at 1 h after radioiodine administration may not be appropriate to predict 24-h thyroid uptake data.
延伸閱讀
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