The Effect of TSH on (superscript 131)I Metabolism by Human Thyroid In-vitro

甲狀腺激素對人甲狀腺在體外碘—131代謝之影響

穆瑞運(J. Y. Mu)

《The Chinese Journal of Physiology》 20卷2期 (1968/12) Pp. 157-167

摘要

本實驗室已能利用組織培養法使甲狀腺組織在體外至少在十二日內保持其形態及機能正常。本實驗利用此方法來觀察不同情況的甲狀腺組織在體外碘之代謝及對甲狀腺激素之反應。若每西西培養基中加入20mU的甲狀腺激素，正常甲狀腺組織的碘－131攝取量較未加甲狀腺激素者為高。甲狀腺激素可以增加甲狀腺低功能結節組織的碘－131攝取量，但對甲狀腺高功能結節組織之作用適得其反。因之甲狀腺組織在體外對甲狀腺激素之反應隨其原來情況而異，但在未作進一步研究前，尚難作肯定之結論。本實驗可證實組織培養法確可用以研究甲狀腺在體外之代謝。

並列摘要

Mu, J. Y. The effect of TSH on (superscript 131)I metabolism by human thyroid in-vitro. Chinese J.Physiol.,20(2):157-167,1969.-The (superscript 131)I metabolism in various states of human intact thyroid and in various states of the gland in-vitro were studied. By means of organ culture technique, the morphology and biochemical activity of thyroid slices could be preserved for 12 days so far, a possible increase of seven days for observation. The differences between the effect of TSH on thyroid tissue in-vitro although detectable in thyroid tissues of different functional states, would warrent no definite conclusions until more extensive and further studies. It is clear that the organ culture tcchnique can be improved for determination of the effect of TSH on the normal or pathological thyroid tissues. Other related points have also been discussed.