- 期刊
A Preliminary SPECT Study of Regional Cerebral Blood Flow in Patients with Major Depression
以單光子放射斷層造影偵測憂鬱症患者之局部腦血流變化
摘要
背景：近年來功能性造影檢查常發現憂鬱症患者腦血流異常。本研究以鎝-99mHMPAO單光子放射斷層造影檢查偵測憂鬱症患者之局部腦血流變化，並評估憂鬱症嚴重性與腦血流變化類型的關係。方法：本研究包括15例經精神科診斷標準DSM-IV認定為憂鬱症的病患，病患之Hamilton分級標準均大於18分，且無精神疾病症狀。病患並依憂鬱症之嚴重性分成三類：7例輕微，6例中度及2例重度。單光子放射斷層造影檢查為靜脈注5mCi鎝-99mHMPAO 1小時後開始造影。結果：15例病患中，5例局部腦血流於副緣腦系統處（兩側額葉、顳葉及基底核）明顯降低；3例於左額葉降低；1例於左顳葉降低：1例於左側基底核降低；另5例未發現異常。憂鬱症嚴重性與局部腦血流變化類型之間無明顯差異。結論：鎝-99mHMPAO翠光子放射斷層造影檢查可有效偵測憂鬱症患者之局部腦血流變化，並發現不同類型的變化，瞭解這些局部腦血流變化的類型有助於憂鬱症的臨床診斷及治療。
並列摘要
Background: Recent functional imaging studies have demonstrated that depressed patients frequently exhibit abnormal brain perfusion. The purpose of this study is to assess the relationship between the severity of depression and the regional cerebral blood flow (rCBF) patterns using 99mTc-HMPAO SPECT images.Methods: Fifteen patients who met the criteria of major depression without psychotic feature and with the score of the Hamilton depression rating scale more than 18 were included. They were also divided into 3 subgroups (7 mild, 6 moderate and 2 severe). The SPECT images were created 1 h after intravenous administration of 15 mCi (555 MBq) 99mTc-HMPAO.Results: The rCBF was markedly decreased in the paralimbic brain regions (bilateral frontal cortices, temporal cortices and basal ganglia) in 5 patients. Three showed hypoperfusion in left frontal areas, 1 in left basal ganglia and 1 in left temporal area. The remaining 5 individuals revealed negative results. The severity of depression correlated poorly with rCBF.Conclusion: 99mTc-HMPAO brain SPECT study is valuable to assess rCBF in patients with major depression. It appears to be different patterns of rCBF in major depression. Recognition of these regional abnormalities may have clinical utility in both diagnosis and treatment of depression.
延伸閱讀
- Wang, Y. Y., Chiu, N. T., Wu, T. J., Weng, C. M., Kuo, W. F., & Sun, Y. N. (2003). 單光子斷層掃描(SPECT)影像腦部變異區之統計辨識方法. Journal of Medical and Biological Engineering, 23(2), 89-96. https://www.airitilibrary.com/Article/Detail?DocID=16090985-200306-23-2-89-96-a
- Lee, C. C., Yang, Y. H., Cheng, C. Y., Kung, M. K., Chang, P. Y., Wei, M. C., Lai, A., & Peng, W. C. (1998). 電腦斷層血管造影偵測正在出血之自發性腦出血. 中華放射線醫學雜誌, 23(4), 155-158. https://www.airitilibrary.com/Article/Detail?DocID=10188940-199808-23-4-155-158-a
- 陳奕筑（2020）。使用靜息態功能性磁振造影探討無預兆偏頭痛患者腦部疼痛相關腦區之功能性連結變化〔碩士論文，高雄醫學大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0011-1008202015022100
- 張嘉麟（2013）。以影像處理技術評估腦內微出血於電腦斷層影像之研究〔碩士論文，中原大學〕。華藝線上圖書館。https://doi.org/10.6840/cycu201301039
- Huang, C. H. (2015). 以高解析度磁振造影技術評估缺血性中風後大腦血管結構與功能 [doctoral dissertation, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2015.02165