核研所動物研究用旋轉式正子放射電腦斷層造影系統之研製

The development of INER rotating positron emission tomography scanner for animal imaging

詹美齡(Meei-Ling Jan) ； 梁鑫京(Hsing-Ching Liang) ； 黃世文(Shin-Wen Huang) ； 唐繼善(Jih-Shan Tang) ； 裴呈志(Cheng-Chih Pei) ； 葉慶凱(Ching-Kai Yeh)

《核子醫學雜誌》 15卷1期 (2002/03) Pp. 13-20

https://doi.org/10.6332/ANMS.1501.003

摘要

核能研究所物理級研發完成一套具有2.73mm空間解析度的小型動物研究用旋轉式正子放射電腦斷層造影系統(Animal Rotating Positron Emission Tomography,ARO-PET)。ARO-PET系統有5.04cm×4.48cm的照野範圍(field of view)，可以做小動物實驗的正子造影。系統以條列模式(list mode)儲存資料，對影像前置處理與影像重建等程式與處理方法均可彈性異動，所以相當適合做為研究用機種。ARO-PET系統具有二維平面投影及三維斷層兩種成像功能。二維平面投影成像無需旋轉偵檢器，功能類似加馬攝影機，可獲得二維的平面投影影像。此成像模式可應用於分析示蹤藥物在體內分佈的特性。三維斷層成像模式可獲得三十一個橫切面斷層影像，此模式類似一般的環式PET系統，惟偵檢器數目較少，需轉動90°才可完成掃描。本文介紹ARO-PET系統(含偵檢器、資料擷取、成像處理)的研製及系統空間解析度的測試結果，此外假體實驗與動物實驗的結果亦將在文內討論。

關鍵字

正子放射電腦斷層造影儀 ； PET ； 正子放射攝影機

並列摘要

A Rotating Positron Emission Tomography(ARO-PET)scanner with 2.73mm spatial resolution was developed at the Physics Division, the Institute of Nuclear Energy Research. The field of view of this system is 5.04cm×4.48cm,which is fit for imaging small animals. The list-mode data storage for flexible pre-and post-reconstruction processes is suitable for research requirements also. By ARO-PET, animals can be imaged in two modes. One is similar to a gamma camera in which the detectors do not need to rotate and a 2-D planar projection imaging is obtained. This mode is used for the initial characterization of bio-distribution of tracers. For the tomographic mode, the detectors are rotated through 90°;thirty-one tomographic images can be obtained. This mode resembles a conventional 3-DPET scan using a partial detector ring. The development of the ARO-PET system(including detectors, data acquisition, imaging)and the spatial resolution performance are described in this paper. The results of the phantom tests and animal tests are presentedalso.

並列關鍵字

positron emission tomography, PET, positron emission camera