18F-FDG PET and (superscript 99m)Tc-MDP Bone Scintigraphy in the Detection of Bony Metastasis from Medullary Thyroid Cancer: A Case Report

氟－18-去氧葡萄糖正子斷層造影與鎝－99m-MDP骨骼閃爍造影在甲狀腺髓質癌骨骼轉移之偵測表現

葉加祿(Chia-Lu Yeh) ； 陳遠光(Yen-Kung Chen) ； 辜啓泰(Chi-Tai Ku) ； 王素貞(Su-Cheng Wang) ； 廖健發(Alfred C. Liao) ； 沈業有(Yeh-You Shen) ； 蘇誠道(Chen-Tau Su)

《核子醫學雜誌》 19卷1期 (2006/03) Pp. 51-56

https://doi.org/10.6332/ANMS.1901.008

摘要

一位患有甲狀腺髓質癌之52歲男性曾經於4年前施行過手術治療（甲狀腺全切除，左頸部淋巴節切除及右側胸壁切除），病人隨後在本院接受骨骼閃爍造影及氟－18-去氧葡萄糖正子斷層造影之術後追蹤。骨骼閃爍造影檢查顯示有少數之骨骼轉移病灶，然而相較之下，氟－18-去氧葡萄糖正子斷層造影檢查顯示全身多處廣泛散佈之骨骼轉移病灶，遠多於骨骼閃爍造影檢查之所見。兩者靈敏度之差異可能與不同之造影機轉及甲狀腺髓質癌骨骼轉移之典型形態特徵有關。相較於骨骼閃爍造影，氟－18-去氧葡萄糖正子斷層造影在甲狀腺髓質癌骨骼轉移之偵測，具有較高之靈敏度。

關鍵字

甲狀腺髓質癌 ； 氟－18-去氧葡萄糖 ； 正子斷層造影 ； 鎝－99m-MDP骨骼閃爍造影

並列摘要

A 52-year-old man with history of medullary thyroid cancer (MTC) received total thyroidectomy and left neck lymph node dissection six years ago and then received wide excision for right chest wall metastases one month later. After operation, he received (superscript 99m)Tc-MDP bone scintigraphy and 18F-fluorodeoxyglucose positron emission tomography (FDG PET) for follow up. The bone scintigraphy revealed only a limited number of metastatic bony lesions. However, in contrast with bone scintigraphy, FDG PET showed wide-spread multiple metastatic bony lesions, much more than that shown by bone scintigraphy. The difference of imaging mechanism and morphologic characteristics of bony metastasis from MTC might attribute to the discrepancy in diagnostic sensitivity in MTC with bone metastasis between FDG PET and bone scintigraphy. As compared with bone scintigraphy, FDG-PET scan showed higher sensitivity for the detection of bony metastasis from medullary thyroid cancer.

並列關鍵字

medullary thyroid cancer ； 18F-fluo-rodeoxyglucose ； positron emission tomography ； 99mTc-MDP bone scintigraphy