Acute myocardial infarction (AMI) is a potentially fatal and often unrecognized complication following acute non-thoracic trauma. We present a 50-year-old male patient who developed AMI after acute tibial fracture. He presented with chest pain and subsequent cardiogenic shock that began after being involved in a car accident. He had type 2 diabetes mellitus which was diagnosed 10 years prior to this admission. Cardiac enzymes were found elevated. His electrocardiogram (ECG) showed ST-segment elevation in leads V1-6. Coronary angiography showed multiple vessel disease. After percutaneous coronary intervention, intra-aortic balloon pump, and extracorporeal membrane oxygenation, his chest pain was relieved and ST elevations on ECG regressed. Acute extraordinary stress may have been responsible for AMI in this patient as a result of sympathetic hyperactivity and blood pressure elevation.