Sjögren's Syndrome and Systemic Amyloidosis Associated with Pulmonary Bullae Formation: A Case Report

索格倫氏症候群及類澱粉樣沉積病併有肺部大泡形成：病例報告

王玠仁(Chieh-Jen Wang) ； 陳培然(Pei-Jan Chen) ； 彭明仁(Ming-Jen Peng) ； 陳天令(Tien-Ling Chen) ； 許清寅(Chin-Yin Sheu) ； 劉洪彰(Hung-Chang Liu) ； 王道遠(T.Y. Wang)

《胸腔醫學》 16卷2期 (2001/06) Pp. 129-135

摘要

我們報告一58歲女性病患，合併有索格倫氏症候群及類澱粉樣沉積病，而以慢性咳嗽呈現。其初始胸部X光影像呈雙側肺野多發性結節，囊腫及線狀浸潤陰影。此病人維持穩定狀況達三年之久而後在經levamisole治療後數月間急速惡化。追蹤之肺部影像檢查顯示嚴重的肺實質破壞及大泡形成。肺部生檢結果顯示廣泛之類澱粉樣陳積及早期輕度惡性淋巴瘤之徵兆。索格倫氏症候群及類澱粉樣沉積病合併肺部大泡形成在以往很少被報告出來，我們相信這是首例此類病人接受levamisole治療的報告。Levamisole對此類病人可能有害，不宜使用。

關鍵字

索格倫氏症候群 ； 類澱粉樣沉積病 ； 大泡

並列摘要

We report a 58-year-old female patient with Sjögren’s syndrome (SS) and amyloidosis who presented with chronic cough. Her initial chest roentgenograph showed multiple bilateral nodules, linear infiltrates and cysts. Her condition remained stable for three years, but then deteriorated progressively a few months after beginning levamisole treatment. Multiple pulmonary bullae were recognized concurrently. A open lung biopsy disclosed nodular amyloidosis and a low-grade malignant lymphoma. SS associated with amyloidosis and pulmonary bullae formation has rarely been reported. We also believe it is the first report of the effects of levamisole in such a condition. A determination of the possible detrimental effects of levamisole may require further study.

並列關鍵字

Sjögren's syndrome ； amyloidosis ； bullae ； levamisole