- 期刊
Solitary Nodular Pulmonary Amyloidosis - A Case Report and Review of the Literature
單一結節的肺部類澱粉沉積合併正子攝影FDG升高之病例報告及文獻回顧
摘要
Amyloidosis is a disease resulting from abnormal extracellular deposits of protein (insoluble amyloid polymers) in body tissues. Amyloidosis is classified into light-chain (AL) and reactive (AA) types. The deposit of these proteins leads to progressive organ injury and even death. However, localized pulmonary amyloidosis is rare and the findings on PET/CT scan are unclear. We herein report a 68-year-old female patient suffering from upper chest pain, and examinations showed a pulmonary nodule. FDG uptake was noted on the PET/CT scan. The diagnosis was made after video-assisted thoracoscopic surgery. This case study suggests that localized nodular pulmonary amyloidosis should be considered as a differential diagnosis of a newly diagnosed solitary pulmonary nodule. Pathologic examination should be performed to distinguish this disease from other diseases, especially pulmonary malignancies.
並列摘要
類澱粉沉積是由不可吸收之類澱粉聚合物所形成不正常蛋白質，在身體組織內的細胞外質沉積所造成的疾病。類澱粉沉積的分類包括ligh-chain型（AL型）和reactive型（AA型），這些類澱粉沉積會逐漸的造成器官受損，進而導致死亡。然而局限性的類澱粉沉澱是很少見的，在正子攝影上的表現也不甚清楚。在此我們報告一個68歲女性，因為胸痛，在檢查後發現有單一的胸部結節，而正子攝影發現此節結對FDG有所升高。結節確切的診斷來自於胸腔內視鏡手術，而此病例告訴我們應該將侷限性的肺部類澱粉沉澱，放進新發現單一肺部結節之鑑別診斷中，而確切的病理診斷是很重要的，尤其是要能夠和肺部惡性癌症區別。
延伸閱讀
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- Chou, Y., Chu, Y. C., Chen, F. F., & Hsiue, T. R. (2002). 肺部結節性類澱粉沉著症仿似轉移性惡性病變：病例報告. 胸腔醫學, 17(3), 276-281. https://www.airitilibrary.com/Article/Detail?DocID=10239855-200209-17-3-276-281-a
- Wang, C. J., Chen, P. J., Peng, M. J., Chen, T. L., Sheu, C. Y., Liu, H. C., & Wang, T. (2001). 索格倫氏症候群及類澱粉樣沉積病併有肺部大泡形成：病例報告. 胸腔醫學, 16(2), 129-135. https://www.airitilibrary.com/Article/Detail?DocID=10239855-200106-16-2-129-135-a
- Liu, C. C., Hsu, P. K., Lin, H. J., & Hsu, W. H. (2010). 在修格連氏症候群病人上以單一肺結節表現的類澱粉沉積症. 胸腔醫學, 25(5), 258-262. https://doi.org/10.29806/TM.201010.0005
- Tsai, Y. C., Chen, Y. T., & Chung, I. W. (2019). 一名低細胞性骨髓化生不良病人的肺蛋白質沉積症－病例報告與文獻回顧. 胸腔醫學, 34(1), 34-39. https://www.airitilibrary.com/Article/Detail?DocID=10239855-201902-201901250011-201901250011-34-39