Chest wall tumors usually present as a slowly enlarging mass causing localized dull pain. Approximately 60% are malignant. Rhabdomyosarcomas are rare and highly malignant tumors sometimes found on the chest wall. They are relatively radioresistant; surgical resection should be combined with adjuvant chemotherapy to achieve the best survival. We report a 56-year-old patient presenting with intermittent chest pain related to movement lasting for 20 days. The physical examination revealed an ill-defined protruding soft tissue mass located on the right anterior chest wall between the 6th and 7th intercostal space. Chest X-ray showed an oval-shaped calcification in the lower right chest wall. Echo-guided needle aspiration was performed. The cytologic examination was highly suggestive of a malignant mesothelioma, and the pathologic examination revealed vimentin-positive sarcoma. After the surgical removal of the chest wall lesion, and a wedge resection of the lung, the final pathologic diagnosis was rhabdomyosarcoma. Chest wall sarcomas, therefore, should be considered in those who suffer from intermittent chest pain, although they are uncommon.