Radiation Recall Dermatitis Induced by Gemcitabine: A Case Report

放射治療復甦性皮膚炎：病例報告

王必勝(Pi-Sheng Wang) ； 陳育民(Yuh-Min Chen) ； 彭瑞鵬(Reury-Perng Perng)

《胸腔醫學》 18卷2期 (2003/04) Pp. 141-144

摘要

放射治療復甦性皮膚炎是指病患接受藥物治療後在原先接受放射治療的部位產生的皮膚發炎性病變。本文描述一個第四期肺腺癌病人在接受gemcitabine之化學治療後發生放射治療復甦性皮膚炎的現象。這是少數gemcitabine引起的放射治療復甦性皮膚炎病例報告之一。這個現象的機轉目前還不清楚。
停用引發此一現象的藥物是治療的原則。而全身或局部的類固醇或抗組織胺的效用也還不清楚。當病患接受化療後在原先接受放射治療的部位產生皮膚病變，而又沒有證據顯示是轉移時，放射治療復甦性皮膚炎應列入考慮。

關鍵字

放射治療復甦性皮膚炎 ； 肺癌 ； 化學治療

並列摘要

Radiation recall dermatitis refers to an inflammatory skin reaction at a previously irradiated area subsequent to drug administration. We present a case with stage IV adenocarcinoma of the lung, who developed radiation recall dermatitis after chemotherapy with gemcitabine. This is one of a few reported cases of radiation recall dermatitis induced by gemcitabine. The mechanism of this phenomenon is still unclear. Discontinuation of the precipitating drug is the general concept in management. The efficacy of systemic/topical steroids or antihistamines remains unclear. Radiation recall dermatitis should be considered when patients undergoing chemotherapy develop skin lesions at a previously irradiated site that showed no evidence of disease progression.

並列關鍵字

radiation recall dermatitis ； lung cancer ； chemotherapy ； gemcitabine