Cutaneous Post-irradiation Angiosarcoma -A Case Report and a Review of the Literature-

放射線治療後皮膚血管肉瘤－病例報告暨文獻回顧－

王淳樺(Chun-Hua Wang) ； 陳國熏(Gwo-Shing Chen) ； 蔡坤寶(Kun-Bow Tsai)

《中華皮膚科醫學雜誌》 21卷2期 (2003/06) Pp. 180-186

https://doi.org/10.29784/DS.200306.0007

摘要

皮膚血管肉瘤是源自於血管內皮細胞罕見的惡性腫瘤，極少發生於腹壁，其致病因子甚為複雜，包括有因放射線治療其他惡性腫瘤所導致的皮膚血管肉瘤。目前只有數個病例報告是骨盆腔內惡性腫瘤接受放射線治療後，於腹壁上罹患皮膚血管肉瘤。吾人提出一位因子宮頸上皮鱗狀細胞癌接受體外放射線治療後八年，於腹壁上罹患皮膚血管肉瘤的病例報告。經由組織病理及組織化學免疫學(包括Vimentn，CD31和CD3的陽性反應；Cytokeratin，S-100和LCA的陰性反應)的確診。雖然該病人於確診後接受手術全切除、皮瓣移植及化學等治療，仍不幸於六個月後因敗血症死亡。我譬整理此病例並回顧自1960至2002年的相關文獻。

並列摘要

Cutaneous angiosarcoma(AS) is a rare malignancy arising from vascular endothelium, and
occurs extremely rarely on the abdominal wall. Several predisposing factors, including external irradi-
ation for another malignancy have been suggested. Few cases of abdominal-wall AS in patients previ-
ously treated with pelvic irradiation for gynecological malignancies have been reported hitherto.
Herein, we describe a patient with squamous cell carcinoma of uterine cervix developed a cutaneous
AS eight years after radiotherapy. The diagnosis was confirmed by histopathological and immunohis-
tochemical studies, which showed positive staining for Vimentin, CD31 & CD34 while negative stain-
ing for Cytokeratin, S-100 & LCA. She received aggressive multi-modality therapy including total
excisin of tumor, skin flap and chemotherapy but died 6 months after the initial diagnosis of AS. The
literature between 1960 and 2002 was also reviewed.

並列關鍵字

Angiosarcoma, Abdominal wall, Irradiation/radiotherapy