Tuberculosis is an infectious, chronic granulomatous disease, and is primarily a pulmonary disease. However, it may also be extra-pulmonary. Tuberculosis of the tongue is very rare and is a consequence of pulmonary tuberculosis or primary tuberculosis of the tongue. We recently came across 2 rare cases of tuberculosis of the tongue. The first case was secondary to pulmonary tuberculosis. The second case was primary tuberculosis of the tongue with coexisting tongue squamous cell carcinoma; this is only the second documented case of this type in the world according to a Medline search. Both patients had painful mucosal lesions of the tongue, but were without any chest discomfort initially. We present the cases of these 2 patients and discuss the epidemiology, mechanism and treatment strategy of tuberculosis of the tongue. A longstanding, non-healing ulcer of the tongue may provide a diagnostic clue for tuberculosis in an endemic area.