Mucormycosis is an opportunistic fungal infection. It occurs in patients with diabetes mellitus, malignancy or long-term steroid use, and in those who are immunocompromised. Usually, it infects the rhinocerebral, pulmonary, cutaneous or gastrointestinal systems [1]. Pulmonary mucormycosis commonly occurs in immunocompromised patients or those with malignancies, but vocal cord mucormycosis is rare and the standard treatment is still inconclusive. We reported a patient with acute myeloid leukemia and type 2 diabetes mellitus suffering from vocal cord mucormycosis infection with the initial presentation of stridor. We treated the patient by intravenous amphotericin B for more than 1 month because he refused surgical intervention. But the patient still expired due to disseminated mucormycosis infection.