鼻咽癌之骨骼轉移分析

Skeletal Metastases from the Nasopharyngeal Carcinoma

黃志仁(Chih-Jen Huang) ； 梁雲(Stephen Wan Leung) ； 連熙隆(Shi-Long Lian) ； 王重榮(Chong-Jong Wang) ； 何耀輝(Yau-Hui Ho) ； 方富民(Fu-Min Fang)

《放射治療與腫瘤學》 1卷4期 (1994/12) Pp. 329-333

https://doi.org/10.6316/TRO/199401(4)329

摘要

This is a restrospective study of skeletal metastases in nasopharyngeal cancer. Between November 1987 and December 1992, 90 cases out of 630 nasopharyngeal cancer patients was found to have skeletal metastases. Multiple sites of abnormal radioisotope uptake in skeletal scintigraphy were found in all patients (100%). Radiologically, the lesions were osteolytic in 60%, mixed osteolytic and osteoblastic in 11% and osteoblastic in 29%. The spine was the most common site of bone metastasis. The distribution of metastatic sites was as follows: thoracic spine (74%), ribs (66%), lumbar spine (22%), pelvic bone (60%), sternum (28%), cervical spine (11%). There were 20 cases of spinal cord compression due to skeletal metastases. Thoracic spine was the most common site (60%), followed by lumbar spine (35%) and cervical spine (5%). In the timing of skeletal metastases, fifty-seven cases (63%) were found to have distant metastases at diagnosis or before completion of radiotherapy. The skeletal metastases of the other 33 cases occurred within 3 years after the completion of radiotherapy, the incidence in the first, second and third year were 64%, 18% and 18% respectively. The survival period for patients with skeletal metastases ranged from 1 to 44 months (median 9.5 months). The 1-year and 2-year actuarial survival rate were 48% and 16% respectively. The group receiving radiotherapy and chemotherapy had a longer survival than radiation alone or supportive treatment group. (p＜0.05)

關鍵字

鼻咽癌 ； 骨骼 ； 遠處轉移

並列摘要

This is a restrospective study of skeletal metastases in nasopharyngeal cancer. Between November 1987 and December 1992, 90 cases out of 630 nasopharyngeal cancer patients was found to have skeletal metastases. Multiple sites of abnormal radioisotope uptake in skeletal scintigraphy were found in all patients (100%). Radiologically, the lesions were osteolytic in 60%, mixed osteolytic and osteoblastic in 11% and osteoblastic in 29%. The spine was the most common site of bone metastasis. The distribution of metastatic sites was as follows: thoracic spine (74%), ribs (66%), lumbar spine (22%), pelvic bone (60%), sternum (28%), cervical spine (11%). There were 20 cases of spinal cord compression due to skeletal metastases. Thoracic spine was the most common site (60%), followed by lumbar spine (35%) and cervical spine (5%). In the timing of skeletal metastases, fifty-seven cases (63%) were found to have distant metastases at diagnosis or before completion of radiotherapy. The skeletal metastases of the other 33 cases occurred within 3 years after the completion of radiotherapy, the incidence in the first, second and third year were 64%, 18% and 18% respectively. The survival period for patients with skeletal metastases ranged from 1 to 44 months (median 9.5 months). The 1-year and 2-year actuarial survival rate were 48% and 16% respectively. The group receiving radiotherapy and chemotherapy had a longer survival than radiation alone or supportive treatment group. (p＜0.05)

並列關鍵字

nasopharynx ； head and neck cancer ； bone distant metastasis