- 期刊
Primary Mucosa-Associated Lymphoid Tissue Lymphoma of the Larynx: A Case Report and Literature Review
原發性喉粘膜相關淋巴組織淋巴瘤：病例報告及文獻回顧
摘要
原發性喉粘膜相關淋巴組織淋巴瘤是一種罕見的原發惡性腫瘤，在過去的文獻中，僅發表過15個病例。我們報告一個早期原發性喉粘膜相關淋巴組織淋巴瘤的病例，同時伴隨有慢性喉炎及胃部幽門螺旋桿菌感染。病患在完成放射線治療六個月後，發現局部復發，之後雖然接受化學治療及抗CD20單株抗體療法，其病情並未獲得有效改善。此病患之後接受全喉切除手術，且連續追蹤16個月並未再有局部復發的情況發生。原發性喉粘膜相關淋巴組織淋巴瘤的治療，目前仍是臨床上的一項挑戰。因此我們回顧文獻中有關粘膜相關淋巴組織淋巴瘤之臨床表現、病態生理、治療策略及預後，並針對此一病患治療效果不彰，提出可能的解釋。
並列摘要
Mucosa-associated lymphoid tissue (MALT) lymphoma in the larynx represents a very rare entity in primary malignant tumors and no more than 15 cases have been reported in the literatures. We present a case diagnosed with early stage MALT lymphoma of larynx associated with chronic laryngitis and gastric H. pylon infection. Local relapse was noted six months after radiotherapy. Recurrent disease revealed poor response for chemotherapy and anti-CD20 therapy. Salvage surgery with total laryngectomy was performed. No evidence of disease was observed after 16 months of follow-up. The treatment of primary MALT lymphoma in the larynx remains a challenge. We review the literatures of the clinical features, pathophysiology, treatment modalities and outcomes of MALT lymphoma, and try to explain the poor treatment result of our case.
延伸閱讀
- Chang, N. J., Chiang, C. H., Huang, B. S., & Perng, R. P. (2004). 與黏膜相關類淋巴組織（MALT）之淋巴瘤－病例報告及文獻回顧. 胸腔醫學, 19(1), 75-81. https://www.airitilibrary.com/Article/Detail?DocID=10239855-200402-19-1-75-81-a
- Wu, K. M., Sheu, C. Y., Tzen, C. Y., & Chen, P. J. (2002). 肺淋巴管平滑肌增生症：病例報告及文獻回顧. 胸腔醫學, 17(3), 303-308. https://www.airitilibrary.com/Article/Detail?DocID=10239855-200209-17-3-303-308-a
- Tan, L. E., Tzan, C. Y., Chen, P. J., & Wu, C. L. (2009). 肺結節性淋巴組織增生：病例報告及文獻回顧. 胸腔醫學, 24(3), 168-174. https://doi.org/10.29806/TM.200906.0007
- 陳建銘（2017）。原發肺臟與唾液腺之黏膜相關淋巴組織淋巴瘤的生物學與治療對策研究〔碩士論文，國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU201704036
- Tsai, Y. M., Huang, M. S., Tsai, J. R., Su, Y. C., Liu, Y. C., & Hwang, J. J. (2008). 原發性肺惡性淋巴瘤－淋巴漿細胞惡性淋巴瘤：病例報告及文獻回顧. 胸腔醫學, 23(2), 95-102. https://doi.org/10.29806/TM.200804.0004