We report a case of a 53-year-old female with occult breast cancer presenting with right axillary lymph nodes metastases. The initial presentation was swelling and pain of right axilla without palpable breast mass. Mammography revealed no mass or microcalcification in breast tissue except multiple hyperdense right axillary lymphadenopathy. Positron-emission tomography scan showed increasing FDG uptake of right axillary and right supuraclavicular lymph nodes. Biopsy of lymph node revealed metastatic carcinoma with positive estrogen receptor and progesterone receptor. These data suggested an occult cancer of the breast with right axillary lymph nodes metastases. The patient received right axillary lymph nodes dissection followed by chemotherapy with lipodox and taxotere. Adjuvant radiotherapy to the right breast and right supraclavicular area was given. The patient is well without evidence of disease after the treatment.