- 期刊
Comparing Intensity-Modulated Radiation Therapy with Conventional Tangential Technique in Treating Left-Sided Breast Cancer
治療左側乳癌使用強度調控放射治療與傳統放射治療之比較
摘要
Background and purpose: To determine whether or not intensity modulated radiation therapy (IMRT) offers a better treatment plan compared with conventional parallel opposed tangential radiation therapy for the left-sided breast cancer patients. Materials and Methods: Between January 2005 and December 2006, we treated 70 patients who had Tis-2N0M0 left-sided breast cancers and underwent breast conservation surgery with or without chemotherapy. Both IMRT and conventional radiotherapy were planned for every patient. After comparing the radiation dose and volume to the heart and lung, and other dosimetric parameters, we then decided which technique to use for individual patient. Conventional radiotherapy was used for 2 patients and IMRT for 68 patients. Results: The mean conformity indexes are 1.47 and 1.08 for conventional radiotherapy and IMRT, respectively (p＜0.05). Radiation dose to the heart, ipsilateral lung, and contralateral lung all can be reduced by 38.7%, 22.9% and 60.9%, respectively, with IMRT. Acute side effects were acceptable. The dose heterogeneity of conventional radiotherapy is greater than IMRT with a large area of cold and hot spots. Conclusions: For the left-sided breast, IMRT can reduce the irradiation dose to the heart and both lungs. It also offers better conformity index and dose homogeneity. However, IMRT delivers very low dose radiation to a larger volume of normal surrounding tissues.
並列摘要
Background and purpose: To determine whether or not intensity modulated radiation therapy (IMRT) offers a better treatment plan compared with conventional parallel opposed tangential radiation therapy for the left-sided breast cancer patients. Materials and Methods: Between January 2005 and December 2006, we treated 70 patients who had Tis-2N0M0 left-sided breast cancers and underwent breast conservation surgery with or without chemotherapy. Both IMRT and conventional radiotherapy were planned for every patient. After comparing the radiation dose and volume to the heart and lung, and other dosimetric parameters, we then decided which technique to use for individual patient. Conventional radiotherapy was used for 2 patients and IMRT for 68 patients. Results: The mean conformity indexes are 1.47 and 1.08 for conventional radiotherapy and IMRT, respectively (p＜0.05). Radiation dose to the heart, ipsilateral lung, and contralateral lung all can be reduced by 38.7%, 22.9% and 60.9%, respectively, with IMRT. Acute side effects were acceptable. The dose heterogeneity of conventional radiotherapy is greater than IMRT with a large area of cold and hot spots. Conclusions: For the left-sided breast, IMRT can reduce the irradiation dose to the heart and both lungs. It also offers better conformity index and dose homogeneity. However, IMRT delivers very low dose radiation to a larger volume of normal surrounding tissues.
延伸閱讀
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