Carotid Stenosis after Radiotherapy for NasopharyngealCarcinoma: Case report and review of literature

鼻咽癌放射治療後之頸動脈狹窄－病例報告及文獻探討

陳建宏(Chien-Hung Chen) ； 張揚沛(Yang-Pei Chang) ； 鄞秀靜(Hsiu-Ching Yin) ； 郭文烈(Wen-Rei Kuo) ； 黃志仁(Chih-Jen Huang)

《放射治療與腫瘤學》 22卷2期 (2015/06) Pp. 159-162

https://doi.org/10.6316/TRO/201522(2)159

摘要

放射線治療後頸動脈狹窄被認為是頭頸部癌症體外放射線治療的罕見併發症。患者可能出現各種症狀，如短暫性腦缺血發作，突發性黑蒙或中風。然而，在此併發症下，出現肌陣攣症狀尚未被報告過。我們描述一位33歲的男子罹患鼻咽癌cT1N1M0第一期，於接受放射線70Gy合併Erbitux化學治療後兩年半，發生左頸部肌陣攣。磁共振血管造影（MRA）顯示有左側近端內頸動脈大約60%的狹窄。他未接受任何針對頸動脈狹窄的侵入性治療，目前其左頸部肌陣攣在每年接受局部肉毒桿菌素注射後，近三年皆獲得良好控制。

關鍵字

鼻咽癌 ； 放射線治療 ； 頸動脈狹窄

並列摘要

Carotid stenosis after radiotherapy has been recognized as a complication of external irradiation to the head and neck resulting from treatment for cancer. However, myoclonus is seldom found. We report on a 33-year-old man diagnosed with nasopharyngeal cancer (NPC) cT1N1M0. He had undergone concurrent chemo-radiotherapy (CCRT) with Cetuximab (Erbitux) and curative radiotherapy (RT) with a dose of 7000cGy in 33 fractions. He developed a myoclonic jerk in the left neck 2.5 years after CCRT. Magnetic resonance angiography (MRA) revealed roughly 60% stenosis of the left proximal internal carotid artery. He did not receive any invasive intervention for carotid stenosis and the neck myoclonus was well controlled by an annual local Botox injection for 3 years.

並列關鍵字

Nasopharyngeal cancer ； Radiotherapy ； Carotid stenosis