- 期刊
運動與吸菸對氧化壓力的影響
Effects of Exercise and Smoking on Oxidative Stress
摘要
Purpose: To investigate the effects of oxidative stress induced by one bout of high-intensity exercise on blood oxidative indicators and activities of antioxidative enzymes in subjects with regular exercise and/or with chronic cigarette smoking. Methods: There were four groups (8 subjects for each group): control group (C group), exercise group (E group), smoking group (S group), and exercise-smoking group (ES group). Subjects performed one bout of high-intensity treadmill exercise (85% VO2max) to volitional exhaustion. Blood samples were collected before and immediately after exercise to analyze plasma lactate, thiobarbituric acid reactive substances (TBARS), oxidized low density lipoprotein (oxLDL), and the activity of antioxidative enzymes in erythrocyte lysate, such as catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx). Paired t test, independent one way ANOVA and two-way (exercise×smoking) ANCOVA were used for statistical analysis. Results: Plasma lactate was significantly higher after exercise than before exercise (p＜.05). Except for plasma lactate, there were no significant differences between trials in all other variables. The GPx activity was significantly higher in ES group than in E group (p＜.05). The SOD activity was significantly higher in E group, S group and ES group in comparison with the C group (p＜.05), and ES group was also significantly higher than E group (p＜.05). The CAT activity was slightly higher in E group than in C group, and also in ES group than in S group, but not statistically. Plasma oxLDL in subjects with cigarette smoking (ES group and S group) was significantly higher than nonsmokers (C group and E group) (p＜.05). However, plasma TBARS showed no significant differences between groups. Conclusion: These results indicated that one bout of high-intensity exercise may not increase oxidative stress on smokers. But different stimulus of origin may have a cumulate effect for the system of antioxidative enzymes. The regular exercisers had higher antioxidative enzymes activity. However, though smokers who have regular exercise had higher antioxidative enzymes activity than that no regular exercise, chronic cigarette smoking may have higher oxidative stress result in catalyzed oxLDL; and increase the risks of cardiovascular disease. The advantages of exercise were not as good as the oxidative injuries of cigarette smoking.
並列摘要
Purpose: To investigate the effects of oxidative stress induced by one bout of high-intensity exercise on blood oxidative indicators and activities of antioxidative enzymes in subjects with regular exercise and/or with chronic cigarette smoking. Methods: There were four groups (8 subjects for each group): control group (C group), exercise group (E group), smoking group (S group), and exercise-smoking group (ES group). Subjects performed one bout of high-intensity treadmill exercise (85% VO2max) to volitional exhaustion. Blood samples were collected before and immediately after exercise to analyze plasma lactate, thiobarbituric acid reactive substances (TBARS), oxidized low density lipoprotein (oxLDL), and the activity of antioxidative enzymes in erythrocyte lysate, such as catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx). Paired t test, independent one way ANOVA and two-way (exercise×smoking) ANCOVA were used for statistical analysis. Results: Plasma lactate was significantly higher after exercise than before exercise (p＜.05). Except for plasma lactate, there were no significant differences between trials in all other variables. The GPx activity was significantly higher in ES group than in E group (p＜.05). The SOD activity was significantly higher in E group, S group and ES group in comparison with the C group (p＜.05), and ES group was also significantly higher than E group (p＜.05). The CAT activity was slightly higher in E group than in C group, and also in ES group than in S group, but not statistically. Plasma oxLDL in subjects with cigarette smoking (ES group and S group) was significantly higher than nonsmokers (C group and E group) (p＜.05). However, plasma TBARS showed no significant differences between groups. Conclusion: These results indicated that one bout of high-intensity exercise may not increase oxidative stress on smokers. But different stimulus of origin may have a cumulate effect for the system of antioxidative enzymes. The regular exercisers had higher antioxidative enzymes activity. However, though smokers who have regular exercise had higher antioxidative enzymes activity than that no regular exercise, chronic cigarette smoking may have higher oxidative stress result in catalyzed oxLDL; and increase the risks of cardiovascular disease. The advantages of exercise were not as good as the oxidative injuries of cigarette smoking.
參考文獻
延伸閱讀
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