海藻酸鈣包覆尤加利精油微膠囊之製備與緩效性之探討

Effect of Sustained Release and Preparation of Alginate Microspheres Encapsulated Essential Oil

柳聰立(C. L. Liu) ； 張志鵬(C. P. Chang)

《華岡紡織期刊》 10卷2期 (2003/06) Pp. 215-222

摘要

本研究以液中硬化包覆法來製備海藻酸鈣微膠囊，使用海藻酸鈉為殼材尤加利精油為芯材，藉由針筒將殼材和芯材滴入氯化鈣溶夜中使殼材硬化形成微膠囊。目的在探討海藻酸鈉濃度、氯化鈣濃度及交鏈時間對膠囊的成形性、包覆率及制放性的影響。結果顯示微膠囊在1.0%海藻酸鈉溶液及2.0%氯化鈣溶液交鏈20min有最佳的成形性及最大的包覆率91.78%。在海藻酸鈉溶液1.5%以上或氯化鈣濃度在2.0%以上或交鏈時間超過20min時，會形成完全封閉型的微膠囊。並經微膠囊壓迫實驗後測試精油之緩釋效果。發現在9.80×104、7.35×104、4.90×104dyne/cm2的壓力下，其揮發極限時間各為326、516、573min，皆較純精油完全揮發時間139min為長，達到預期的延長緩釋效果。

關鍵字

微膠囊 ； 海藻酸納 ； 液中硬化包覆法 ； 緩效法

並列摘要

In this study, calcium microspheres encapsulated eucalyptus essential oil was prepared by a orifice method. The parameters of optimal oil content, concentration of crosslinking agent, treated time, release properties etc. were investigated. The results indicated that the optimal of oil content was 91.8% at condition of 1% sodium alginate aqueous solution and 2% of crosslinking agent CaCl2. The alginate microspheres was became a closed type at conditions of ＞1.5% alginate or ＞2% CaCl2 or crosslinking time ＞20min. The limit release time of ruptured microcapsules were 326min, 516min under 9.80×104, 7.35×104, 4.90×104 dyne/cm2, respectively. The effect of sustained release was improved compared the oil released data with limit time 139min of pure oil without encapsulated wall material.

並列關鍵字

microcapsules ； sodium alginate ； eucalyptus oil ； orifice ； controlled release