The objective of this research was to explore the relationship among motivational orientations, learning stress, and anxiety. The study, based on the questionnaire survey from the educational field, used hierarchical multiple regression analysis to examine learning strategy as a moderator variable between motivational orientations and learning stress and learning stress as a mediating variable. The study results indicated that 1. learning motivational orientation had a negative effect on learning anxiety, while achievement motivational orientation had a positive effect. 2. Hindrance stress mediated the relationship between motivational orientations and learning anxiety. 3. Recognition and emotional strategies moderated the relationship between learning orientation and hindrance stress, The research result indicated the importance of the roles of stress types and learning strategy in the learning stress.