This paper set to examine the regulation pertaining to the occupation of genetic information for insurance underwriting in Taiwan and the rest countries of the world. After that, the legal rationale of positive and negative points of view bearing on utilizing the genetic information in insurance industry was discussed. Looking forward, when it becomes pervasive situation that people purchase the long term care insurance and critical illness insurance to cover medical care expenses, then, the issue mentioned above should turn to more essential. For future's policy making purpose, it is necessary to clarify and understand the contemporary regulation concerning apply genetic information to insurance industry.