The purpose of this research is to find out the principal approaches and justification of the Indo-US bilateral cooperation. India relies on the U.S. for security reasons in the Indo-Pacific and its neighborhood. Further, India has severe security threats from its neighborhood in the northern and Himalayan frontier borders. In this prospect, this research investigates the bilateral cooperation of both countries. Why is the U.S. more important to India for the purpose of security and defense sectors in South Asia and the Indo-Pacific region? The investigation of this study uses the comparative method with an analytical approach. As a result, the Indo-US strategic partnership is on the right track, and there is no conflict of interest in the Indo-Pacific at the global level. Furthermore, this research recommends that India needs to win the hearts of its South Asian neighborhood to restrict Chinese involvement in these countries.