Pasini與Pierini氏皮萎症是一種罕見但極具臨床特徵的疾病,典型皮膚病灶為境界鮮明、稍微下陷並帶有石灰色或棕色的斑,病人通常無自覺症狀,且病灶常雙側對稱出現。我們報告一例15歲女孩,最近3年來在其左側手臂及背部出現數個呈帶狀排列、稍微下陷的棕色斑。我們在其左側腰部進行皮膚切片,取下的組織包括正常皮膚與下陷部位,病理檢查發現在真皮深處局部有膠原纖維增厚及均質化的現象,因此我們診斷其為Pasini與Pierini氏皮萎症。
Atrophoderma of Pasini and Pierini (APP) is a rare but clinically distinct skin disease characterized by sharply demarcated, slightly depressed patches with a slate-gray or brown color. The lesions are usually asymptomatic, bilateral and symmetrical. We report a 15-year-old girl who had a 3-year history of unilateral band-form, brownish, slightly depressed patches over the left arm and back. A skin biopsy from the left flank lesion including clinically normal skin and a depressed area was performed. The histopathologic study revealed thickening of the collagen fibers with homogenization in focal areas of reticular dermis at the lesion site, which is consistent with APP.