摘要
神經束膜瘤是起源於神經束膜的一種罕見腫瘤。在電子顯微鏡下，其特徵為具有外板、胞飲作用囊泡、中間斯及細胞膜電子緻密斑塊等超微構造。免疫組織化學染色則顯示該腫瘤細胞對vimentin及上皮細胞膜抗原具有免疫反應活性，但對S-100蛋白質則無反應。硬化性神經束膜瘤乃是最近才被報告的一種神經束膜瘤的變異型，它具有特定的臨床與組織病理特徵：臨床上典型的表現為一無痛感之小型皮膚腫瘤，好發於年輕成人的手指與手掌；組織病理檢查則顯示有許多粗厚的膠原蛋白束，其間散在分佈一些小型的表皮樣或紡錘狀細胞，這些細胞並呈現索狀、樑柱狀或漩渦狀的生長型態。我們在此報告二例硬化性神經束膜瘤的病例報告，同時並將以往英文文獻中所報告过病例加以整理回顧。
關鍵字
無資料並列摘要
Perineurioma is a rare tumor originated from perineurium. In electron microscope, the perineurial cell is characterized by the presence of external lamina, occasional pinocytotic vesicles, scattered intermediate filaments and electron-dense cell membrane plaques. Immunohistochemically, the perineurial tumor cells are reactive for vimentin and epithelial membrane antigen (EMA) but negative for S-100 protein. Sclerosing perineurioma is a recently described variant of perineurioma with distinctive clinical and histopathologic features. It typically presents as a small, painless, dermal or subcutaneous mass involving the digits and palms of young adults. Histopathologically, it showed abundant, thick, collagen bundles and scattered small epithelioid or spindled cells with corded, trabecular or whorled (onion bulb-like) growth patterns. We herein report two cases of sclerosing perineurioma. Previously published cases in English language literature are also reviewed.
延伸閱讀
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- Chen, S. L., Yu, S. Y., Hsu, T. N., Huang, M. S., & Huang, C. S. (2021). 硬顎咀嚼粘膜孤立局限性神經瘤－病例報告. 臺灣口腔顎面外科學會雜誌, 32(1), 57-66. https://www.airitilibrary.com/Article/Detail?DocID=a0000494-202103-202106020012-202106020012-57-66