- 期刊
Cutaneous Metastatic Breast Carcinoma Mimicking Malignant Melanoma
皮膚轉移性乳癌疑似惡性黑色素瘤
摘要
皮膚轉移性乳癌疑似惡性黑色素瘤是一罕見的疾病，臨床的表現為在乳癌上方的皮膚或乳癌切除疤痕附近出現深色到黑色的丘疹，病理檢查可見富含黑色素的黑色素細胞散佈在表皮下乳癌細胞之中。我們報告一個56歲的女性乳癌患者，在手術六年後，長出數個深色到黑色的丘疹於先前乳房切除術疤痕上。在這個病例中，乳癌細 胞浸潤於整個真皮中，另可見樹突狀的富含黑色之細胞聚集於上層真皮中。癌細胞的cytokeratin 與estrogen及progesterone受體染色皆為陽性反應，富含黑色素的細胞則為S-100蛋白和HMB-45染色陽性。
關鍵字
無資料並列摘要
Cutaneous metastatic breast carcinoma mimicking malignant melanoma, is a rare condition manifested clinically by hyperpigmented to black papules scattered on the overlying skin of the breast carcinoma or near the postmastectomy scars of breast carcinoma, and histopathologically by the dispersion of melanin-laden melanocytes at the subepidermal area amongst the breast carcinoma cells. We report a case of a 56-year-old female with breast cancer who developed multiple hyperpigmented to black papules over the postmastectomy scars six years after the operation. In this case carcinoma cells infiltrated the whole dermis and dendritic melanin-laden cells were found in aggregates in the upper dermis. The carcinoma cells were positive for cytokeratin, and both estrogen and progesterone receptors, and the melanin-laden cells were positive for S-100 protein and HMB-45.
延伸閱讀
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