Intralesional Methotrexate as Effective Treatment in Solitary Keratoacanthoma of Nose -A Case Report-

成功以局部注射Methotrexate治療角質棘皮瘤─病例報告─

許仲瑤(Chung-Yee Hui) ； 陳建勳(Chien-Hsun Chen) ； 曾興隆(Heng-Leong Chan)

《中華皮膚科醫學雜誌》 20卷1期 (2002/03) Pp. 63-67

摘要

角質棘皮瘤的治療方法很多，以完全切除為主要的治療方式。但若碰到長得很大或在美容重要部位的時候，切除加補皮的美觀效果不佳，可考慮用局部注射的方法。文獻上可用於局部注射的藥物有5-fluorouracil, bleomycin, methotrexate及α干擾素。我們報告一例長在鼻翼並延伸到鼻腔內的角質棘皮瘤，經兩次methotrexste局部注射，在3星期後消退的成功個案。局部注射methotrexate在治療單一大型角質棘皮瘤比其他局部注射藥物能有較輕濟、快速、不疼且簡單的效果，是一個值得推薦的治療方式。

並列摘要

There are many methods to treat keratoacanthoma. Surgical excision is the treatment of choice for majority of keratoacanthoma. However, significant cosmetic defects can result if large or cosmetically important location are involved. Intralesional therapy with 5-fluorouracil, bleomycin, methotrexate or interferon- α has been shown to be effective in treatment in these cases. We report a case of keratoacanthoma on nasal ala with extension to nasal cavity resolved in 3 weeks after treated with intralesional methotrexate after 2 injections. We concluded that intralesional methotrexate is a simple and effective treatment for solitary giant keratoacanthoma. It offers greater efficacy, more rapid course, decreased pain and lower cost compared with other intralesional agents and deserves recommendation.

並列關鍵字

Keratoacanthoma ； Intralesional treatment ； Methotrexate