Lupus Erythematosus Like Skin Lesions Induced by Tegafur-Uracil - A Case Report -

Tegafur-Uracil 引起之類似紅斑性狼瘡的皮膚病灶－病例報告－

李凱國(Kai-Kuo Lee) ； 趙曉秋(Sheau-Chiou Chao) ； 李玉雲(J. Yu-Yun Lee)

《中華皮膚科醫學雜誌》 22卷2期 (2004/06) Pp. 173-177

https://doi.org/10.29784/DS.200406.0008

摘要

UFUR為一種綜合了uracll 和tegafur 這兩種藥物的第2抗癌藥。少數的皮膚疾病與接受UFUR的治療有關。本篇報告一例69歲罹患胃癌男性病患服用UFUR大約兩周時，出現類似紅斑性狼瘡的皮膚病灶。而根據發現有典型皮膚紅斑性狼瘡的組織病理特徵，以及有陽性反應的抗核抗體（包括點狀和核仁型態），以及抗Ro和抗La抗體，診斷為藥物所引發的紅斑性狼瘡。皮膚病灶停藥並接受類固醇治療後，約兩周內緩解。但再次給藥時又再度地復發。這是台灣首例報告因服用UFUR引發類似紅斑性狼瘡的皮膚病灶。UFUR應被列為在接受治療時，會引發類似紅斑性狼瘡病灶可能的原因。（中華皮誌22 : 173－177 , 2004 )

並列摘要

Tegafhr-Uracil (UFUR) is a second generation anticancer agent. Few skin lesions are associated with UFUR therapy. Skin lesions with features of lupus erythematosus occurred in a 69-year-old man after starting UFUR treatment for 2 weeks for gastric adenocarcinoma. The diagnosis of drug-induced lupus erythematosus was supported by classic histopathologic findings of cutaneous lupus erythematosus, positive antinuclear(speckled and nucleolar pattem), and anti-SSA/Ro and SSB/La antibodies. The skin lesions resolved within 2 weeks after discontinuation of UFUR and treatment with steroids, but recurred on readministration of UFUR. This may be the first reported case of UFUR- induced lupus erythematosus-like skin lesions in Taiwan. UFUR should be considered as a possible cause of lupus erythematosus-like skin lesions during UFUR therapy. (Dermatol Sinica 22: 173-177, 2004)

並列關鍵字

UFUR ； Lupus erythematosus-like skin lesions