骨髓分化不良徵候群合併出現皮膚白血病―一病例報告―

Myelodysplastic Syndrome Complicated with Leukemia Cutis-A Case Reprot-

吳育欣(Yu-Hsin Wu) ； 楊仁宏(Jen-Hung Yang) ； 沈瑞隆(Jui-Lung Shen)

《中華皮膚科醫學雜誌》 22卷3期 (2004/09) Pp. 248-253

https://doi.org/10.29784/DS.200409.0006

摘要

我們報告一五十歲女性，罹患骨髓分化不良徵候群之頑固型貧血伴隨過多母細胞(blasts)亞型的病例，該病患接受保守治療、免疫抑制劑治療，但效果不甚理想。一年之後，其軀幹、四肢皮膚出現多發性、無症狀、紅色丘疹、斑塊及結節，組織病理學及免疫組織化學檢查顯示真皮層中充滿非典型單核細胞浸潤，其CD45及myeloperoxidase呈陽性反應，故診斷為皮膚白血病，稍後的骨髓穿刺切片證實為急性骨髓性白血病，雖經積極的化學治療，此病例卻於一周之後死於腦內出血。

並列摘要

We herein presented a 50-year-old female of myelodysplastic syndrome sub-typing refractory anemia with excess blasts. She had received conservative and immunosuppressive therapies, but not controlled well. One year later, multiple asymptomatic, erythematous papules, plaques and nodules developed over trunk and four limbs. The histopathological and immunohistochemical studies showed atypical mononuclear cells infiltrate positively stained with CD45 and myeloperoxidase in the whole dermis, indicating the diagnosis of leukemia cutis. Then, the bone marrow biopsy was suggested and acute myeloid leukemia was diagnosed. In spite of vigorous chemotherapy, the patient died of intra-cerebral hemorrhage in one week.

並列關鍵字

Myelodysplastic syndrome ； Leukemia cutis ； Acute myeloid leukemia