Systemic Contact Dermatitis from Valacyclovir-A Case Report and Review of the Literature

Valacyclovir引起系統性接觸性皮膚炎－病例報告與文獻回顧

楊政翰(Cheng-Han Yang) ； 朱家瑜(Chia-Yu Chu)

《中華皮膚科醫學雜誌》 25卷1期 (2007/03) Pp. 24-29

https://doi.org/10.29784/DS.200703.0005

摘要

Acyclovir是一種廣泛使用的抗病毒藥物，但是acyclovir引起過敏性接觸性皮膚炎的案例卻很少。我們在此報告一例48歲女性，因右上肺腺癌入院接受肺葉切除手術，手術後由於使用局部acyclovir藥膏而致敏化，隨後於口服valacyclovir及塗抹acyclovir藥膏時發生系統性接觸性皮膚炎。在三十三個自願受試者中，對於acyclovir(10%aq.)貼膚試驗皆呈現陰性反應。我們同時也回顧了醫學文獻，並探討如何藉由貼膚試驗診斷藥物過敏的方法。

並列摘要

Acyclovir is a widely used antiviral drug. However, allergic contact dermatitis caused by acyclovir is uncommon. We herein report a 48-year-old woman, who had been diagnosed as having adenocarcinoma of the upper lobe of the right lung, developed systemic contact dermatitis sensitized by topical acyclovir therapy first, and triggered by re-exposure of oral valacyclovir and topical acyclovir therapy. A control study of 33 healthy volunteers patch tested with acyclovir (10% aq.) showed they were all negative to this preparation. We also reviewed the literature and discussed the methods of patch testing in diagnosing drug allergy.

並列關鍵字

Acyclovir ； Allergic contact dermatitis ； Patch test ； Valacyclovir