Since the invention of guided tissue regeneration in human oral reconstruction in 1982, the materials utilized have been developed from a nonabsorbable minipore membrane to bioabsorbable materials. Dental practitioners should be familiar with the biological properties, clinical indications, and factors affecting the therapeutic outcome of regenerative procedures in order to achieve best clinical results. Peri-Aid is a new collagen membrane in Taiwan. The purpose of this paper is to review the material properties and clinical documentation of collagen membrane in the management of intrabony defects. Two case reports concerning the clinical procedures and efficacy of Peri-Aid in the treatment of human intrabony defects are also presented.