- 期刊
前列腺素E2於牙周炎之重要性
The Importance of Prostaglandin E2 in Periodontal Disease
摘要
近代研究學者希望能夠於臨床找出定量牙周疾病的方法。經過近十多年的研究，前列腺素E2被發現和牙周疾病的進行有很密切的關係，前列腺素E2已然成為標定牙周疾病的化學介質。針對這一個研究主題，我們希望可以透過前列腺素E2的生合成、釋放的誘導機制，窺探前列腺素E2在生物體中所扮演的角色；經由前列腺素E2在發炎反應上的影響，再間接引證出前列腺素E2和牙周組織發炎的關聯；並藉前列腺素E2對牙周疾病的預測性、和骨質喪失的關係、在高危險群的病患中前列腺素E2所產生影響、前列腺素E2和不同牙周疾病的相關性，對前列腺素E2和牙周疾病之間做一個更完整的論述；最後再探討非膽固醇類消炎藥物，影響前列腺素E2生合成的藥理調節機制，運用在治療牙周疾病的應用，使牙周疾病的治療能夠順利的邁向下一個里程碑。
並列摘要
In past decades, PGE2 was detected at significant level in periodontal diseased tissue for the diagnosis of periodontal disease. PGE2 has diverse effects such as vasodilation, immunoregulation, and bone resorption in the process of periodontal inflammation. Is also regulates the production of metalloproteinase and proinflammatory cytokines in human inflamed gingival tissue. In the present review, the association of PGE2 and the pathogenesis of periodontal disease were discussed. The effects of PGE2 in some systemic diseases, such as diabetes mellitus, were also dictated as a high risk factor for periodontal disease. Furthermore, the effect of NSAIDs on PGE2 production and its pharmaceutical kinesis were also discussed for the treatment of periodontal disease.
延伸閱讀
- Wang, Y. T. (2011). 前列腺素E2對人類牙髓細胞分化及基因表現的影響 [master's thesis, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2011.02286
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