臨床前粥狀動脈硬化與牙周炎之關係：文獻回顧

The Relationship between Subclinical Atherosclerosis and Periodontitis: Review of Literatures

陳勇利(Yung-Li Chen) ； 呂炫堃(Hsein-Kun Lu)

《中華民國牙周病醫學會雜誌》 10卷3期 (2005/09) Pp. 219-228

摘要

粥狀動脈硬化之併發症，包含冠狀動脈心臟病和中風，是造成人類的主要死因。現今認為粥狀動脈硬化屬於一種血管的炎性反應，而某些感染性疾病可能是它的危險因子。牙周炎是由細菌感染所引發，是造成口腔感染主要原因之一，近年來也已被證實可能會藉由牙周致病原的直接或間接因子對粥狀動脈硬化的發生造成影響。由於牙周炎與粥狀動脈硬化於臨床上具有相同之危險因子，如抽煙，糖尿病遺傳體質等；本文將近年來有關這兩者疾病的相關研究，做一橫向流行病學與病理學之整理，並解釋牙周炎與臨床前粥狀動脈硬化可能存在的因果關係，以釐清並建立未來縱向臨床研究所需的方向。

關鍵字

牙周炎 ； 臨床前粥狀動脈硬化 ； 共同危險因子

並列摘要

Atherosclerotic complications, including coronary heart disease and stroke, are the main cause of human death. Up to date, it is assumed that atherosclerosis is an inflammatory vascular condition, and certain infectious disease may cause the burst of atherosclerosis and possibly be part of its risk factors. Periodontitis, perceived as an infectious disease induced by bacteria, is one of the major cause of oral infection and has also been proved to contribute to the pathophysiology of atherosclerosis via direct or indirect invasion of periodontal pathogens in recent years. This article was to review relevant literatures which are associated with the cross link of preclinical atherosclerosis and periodontitis. The common etiologic risk factors of these two diseases will be discussed and be elucidated their possible links. We try to high light the debated points and construct an assumption for the construction of a longitudinal clinical or wet laboratory investigation in the near future.

並列關鍵字

periodontitis ； atherosclerosis ； common risk factors