Deep intraosseous defects represent a major challenge for the clinician. The intrabony defects in subjects who had not received systematic periodontal therapy have been substantiated as higher risks in disease progression. The surgical treatments of angular defects include osseous resective and reconstructive therapy. Guided tissue regeneration (GTR) is the most frequently documented reconstructive procedure. We provide a patient who was diagnosed as generalized mild and localized severe chronic periodontitis with a deep angular defect at the mesial root of her mandibular first molar. After flap elevation and thorough root planing, a polylactic acid biosorbable membrane and decalcified freeze-dried bone allografts were utilized in the defect. The clinical outcome evaluated by periodontal examination including probing depth, attachment level and radiographic bone f ill was satisfactorily. We hope to enhance clinical result of guided tissue regeneration in the angular defect and provide a treatment modality with high predictability.