Mesenchymal stem cells (MSCs) can be induced differentiation into osteoblasts. chondrocytes and adipocytes. Osteoblasts can improve regenerative result in periodontology. Most of the reports isolate MSCs from the bone marrow, In oral tissues, MSCs were founded and isolated from dental pulp ' deciduous dentition and periodontal ligament in recent researches. There were more and more researches about MSCs mediated periodontal regenerative therapy. This is a literature review on the effect of the periodontal regenerative therapy combined with stem cells.