Patients with periodontitis often need combined treatment with orthodontic therapy. However, the time for carrying out orthodontic intervention is still not well defined. This article reviews the key points related to the interdisciplinary treatment of periodontal and orthodontic therapy, including the characteristics of the periodontitis patients receiving orthodontic tooth movement, the influence of orthodontic force upon periodontal tissue, whether orthodontic treatment can be performed immediately after regeneration therapy, the impact of bone graft material on the rate of tooth movement, and other factors. In addition, a clinical case is outlined for discussion. The results of the literature review show that periodontal regeneration should be performed before orthodontic therapy, especially when the site has a intrabony defect. After periodontal attachment has been reconstructed, the periodontal status is more favorable for orthodontic therapy. In our case, orthodontic treatment took place after 3 months of regeneration surgery. An attachment level gain of 3.25 mm was found at 14 months post-surgical follow up. This review shows that orthodontic treatment has no detrimental effect on the newly regenerated tissue. Our clinical results offer a treatment option for multidiscipline decision making.