血小板衍生生長因子於牙周組織再生之應用：文獻回顧

The Use of Platelet-Derived Growth Factor during Periodontal Regeneration: A Literature Review

劉諭(Yu Liu) ； 郭博仁(Po-Jan Kuo) ； 張迺旭(Nancy Nie-Shiuh Chang) ； 江正陽(Cheng-Yang Chiang) ； 傅鍔(Earl Fu) ； 沈一慶(E-Chin Shen) ； 邱賢忠(Hsien-Chung Chiu)

《臺灣牙周病醫學會雜誌》 21卷1期 (2016/03) Pp. 60-72

https://doi.org/10.6121/TAP.2016.21.1.07

摘要

血小板衍生生長因子(platelet-derived growth factor, PDGF)在牙周傷口癒合中扮演重要角色：能增進血管新生，調節間葉細胞生長分化，吸引並促進骨細胞再生。臨床上應用血小板衍生生長因子於自然牙周圍則能促進軟、硬組織早期癒合，得到完整牙周再生。應用於待植牙的無牙嵴再生則可在短時間獲得良好骨質，縮短植體贋復所需等待時間。透過本文獻回顧討論血小板衍生生長因子應用在各類牙周及植牙手術術式之成效，讓臨床醫師 對其認識更深，對未來解決臨床困境又多一利器。(臺灣牙周醫誌，21(1):60-72, 2016)

關鍵字

血小板衍生生長因子 ； 牙周再生 ； 牙齦覆蓋 ； 齒嵴豐隆術

並列摘要

Platelet-derived growth factor plays a significant role in periodontal wound healing; it does this by promoting angiogenesis, stimulating mesenchymal stem cell differentiation and recruiting/promoting osteoblast formation. Clinical application of PDGF during periodontal regeneration may promote the early healing of both soft and hard tissue. Histological studies have revealed complete periodontal regeneration, including the periodontal ligament, cementum and alveolar bone. The use of PDGF during ridge augmentation and sinus augmentation as part of implantology is able to achieve mature bone more quickly and this shortens the treatment time when implanting a support prosthesis. This review of studies investigating the cell biology of PDGF and its application in periodontology and implantology is able to provide clinicians in future practice with additional validation of their use of a growth factor that brings about tissue-engineering. (J Taiwan Periodontol, 21(1):60-72, 2016)

並列關鍵字

platelet-derived growth factor ； periodontal regeneration ； root coverage ； ridge augmentation